The Correlation between Multidrug Resistance Gene Polymorphism and Plasma Concentration of Risperi-done and Its Metabolite
10.6039/j.issn.1001-0408.2016.26.01
- VernacularTitle:多药耐药基因多态性与利培酮及其代谢物血药浓度的相关性
- Author:
Jiang LOU
;
Wei YAN
;
Gang WANG
;
Ping XU
;
Huande LI
;
Fei WANG
- Publication Type:Journal Article
- Keywords:
Multidrug resistance;
Gene polymorphism;
Risperidone;
9-hydroxyrisperidone;
Total active substance;
Plasma concentration/dose calibration ratio;
Correlation
- From:
China Pharmacy
2016;27(26):3601-3604
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To discuss the correlation between multidrug resistance gene (MDR1) polymorphisms and plasma concentration of risperidone,9-hydroxyrisperidone and total active substance in Han patients with schizophrenia. METHODS:78 Han inpatients with schizophrenia in Mental Health Institute of Second Xiangya Hospital of Central South University from Dec. 2011 to Jan. 2013 were selected,LC-MS/MS was conducted to determine the plasma concentration of risperidone,9-hydroxyrisperi-done and total active substance,PCR-LDR was adopted to determine the genotyping of C1236T,G2677T and C3435T of patients, and one-way ANOVA was used to detect the correlation between C1236T,G2677T and C3435T polymorphisms and plasma concen-tration/dose calibration ratio (C/D) value of risperidone,9-hydroxyrisperidone and total active substance. RESULTS:The average plasma concentrations of risperidone,9-hydroxyrisperidone and total active substance for 78 patients were(13.58±8.31),(25.62± 15.52)and(39.24±25.76)ng/ml,respectively;the distribution frequencies of C1236T,G2677T and C3435T met the Hardy-Wein-berg equilibrium(P>0.05);the risperidone C/D value of patients with C12367T CT and TT genotype were higher than those with CC genotype,risperidone and total active substance C/D values of patients with G2677T TT genotype were higher than those with GG genotype,the differences were statistically significant (P<0.05);while there were no significant differences in analyte C/D values in other patients(P>0.05). CONCLUSIONS:The MDR1 C1236T and G2677T polymorphisms are associated with plasma concentration of risperidone and total active substance in Han patients with schizophrenia.
