Application and Comparison of 3 Kinds of Diagnostic Criterion for Drug-induced Liver Injury
10.6039/j.issn.1001-0408.2016.26.10
- VernacularTitle:3种药物性肝损伤诊断评分系统的应用及比较
- Author:
Qin XU
;
Hao LIU
;
Yuexin ZHANG
- Publication Type:Journal Article
- Keywords:
Drug-induced liver injury;
Diagnostic criterion;
RUCAM;
Maria standard;
DDW-J standard
- From:
China Pharmacy
2016;27(26):3633-3635
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To analyze and compare the congruity between Maria and DDW-J standard and Roussel uclaf causali-ty assessment method(RUCAM)for diagnosing drug-induced liver injury(DILI),and evaluate its application. METHODS:In ret-rospective analysis,the clinical data of 122 patients with DILI with RUCAM ≥3 scores was quantitatively scored by Maria and DDW-J standard,χ2 test was conducted for statistical analysis. RESULTS:Among the 122 cases,120 cases(98.4%)were classi-fied as“likely and possible”by DDW-J standard,which was significantly higher than the 58 cases(47.5%)that classified as“pos-sible”by Maria standard,with statistical significance;and compared with Maria standard,DDW-J standard was more closer to RU-CAM scoring results. CONCLUSIONS:DDW-J standard is superior to Maria standard,and close to RUCAM scoring results for DI-LI;RUCAM is still the DILI diagnostic evaluation system with high accuracy and operability.
