Analysis of 58 Cases of ADR/ADE with Cardiac Damage Induced by Metranidazole

VernacularTitle:甲硝唑致心脏损害58例不良反应/事件分析
Author: Li WANG ; Xiaojie ZHOU ; Huixia ZHANG
Publication Type:Journal Article
Keywords: Metranidazole; Cardiac damage; Adverse drug reaction/event; Analysis
From: China Pharmacy 2016;27(26):3643-3645
CountryChina
Language:Chinese
Abstract: OBJECTIVE:To explore the characteristics and regularities of cardiac damage induced by metranidazole,and pro-vide reference for clinical safe application. METHODS:In retrospective study,58 cases of cardiac damage caused by metranidazole in Henan ADR Monitoring Center for Drug from Jan. 2010 to Dec. 2015 were analyzed statistically. RESULTS:In 58 cases of cardiac damage induced by metranidazole,25 cases were male,33 were female,the ratio of male to female was 0.76∶1,the patients with ADR/ADE aged 15-64 years (74.14%),most were intravenous administration (79.31%) and happened within 30 min (70.69%), cardiac damage mainly manifested as palpitation,severe cases can cause tachycardia and arrhythmia,the ADR improved or cured af-ter withdrawal or symptomatic treatment. CONCLUSIONS:Clinic should strengthen observation of ADR/ADE caused by metranida-zole,especially the monitoring of cardiac toxicity reactions;pharmaceutical manufacturers should improve the drug instructions to in-sure the safety of clinical medication.