Alteration of oxidative stress in peripheral blood of first-episode schizophrenia
10.3969/j.issn.1002-0152.2016.08.001
- VernacularTitle:首发精神分裂症外周血氧化应激状态改变
- Author:
Yangyang CHAO
;
Weiyong SHENG
;
Jin ZHAO
;
Yuzhong SHI
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Oxidative stress;
Antipsychotic drug
- From:
Chinese Journal of Nervous and Mental Diseases
2016;42(8):449-453
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the status of oxidative stress (OS) in the first-episode schizophrenia patients (FEP) and to examine the effects of antipsychotic drugs on oxidative stress of FEP. Methods The plasma total superox?ide dismutase (T-SOD), glutathione peroxidase (GSH-Px), catalase (CAT) and total antioxidant capacity (T-AOC) were measured in forty-seven FEP (case group) and forty-three healthy volunteers (control group) before and after treatment. Eighteen cases completed 6-week treatment with risperidone (risperidone group) and twenty-five cases completed 6-week treatment with olanzapine (olanzapine group). Results The activity of T-SOD and GSH-Px were lower (P<0.05) and CAT was higher (P<0.05 ) while there was no significant difference in T-AOC (P>0.05) in FEP compared to the control group. Risperidone and olanzapine significantly improved T-SOD and T-AOC, respectively (P<0.05). There was no significant difference between the two groups in the changes of oxidative stress indicators after treatment (P>0.05). Conclusion FEP has alterations of antioxidant enzymes, which may be related to the pathogenesis of schizo?phrenia. Antipsychotics risperidone and olanzapine may improve the oxidative stress in FEP.
