Effects of Compound Kushen Tang on Ulcerative Colitis in Rats and the Underlying Mechanism
- VernacularTitle:复方苦参汤对溃疡性结肠炎模型大鼠的干预及作用机制研究
- Author:
Chengzhi ZHOU
;
Nan JIANG
;
Conghui ZHOU
;
Wanjin SUN
;
Wei SUN
;
Xiulan WANG
;
Tianmi ZHU
;
Songtao WU
;
Jia YANG
;
Xueyun DUAN
;
Heng FAN
- Publication Type:Journal Article
- Keywords:
Ulcerative colitis;
Compound Kushen Tang;
Antioxidation
- From:
China Pharmacist
2016;19(10):1816-1820
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the therapeutic effects of compound Kushen Tang and its relevant mechanism in TNBS-in-duced ulcerative colitis ( UC) rats. Methods:UC was induced by TNBS in rats. After compound Kushen Tang was given orally, the levels of MDA, iNOS, and NO and the activity of MPO, SOD, and GSH-Px were measured. The general condition of rats and colon tissue morphology were observed. Results:The levels of MDA (P<0. 05), iNOS (P<0. 01) and NO (P<0. 01) and the activity of MPO (P<0. 01) in tissues of UC rats were significantly higher than the control group. The activity of SOD (P<0. 01) and GSH-Px (P<0. 05) were significantly lower than those in the control group. After the treatment with high doses of compound Kushen Tang, the levels of MPO (P<0. 01), MDA (P<0. 05), iNOS (P<0. 05) and NO (P<0. 01) were significantly decreased, and the activity of SOD (P<0. 01) and GSH-Px (P<0. 05) significantly increased. The therapeutic effect was dose-dependent and the general con-dition of rats and colon tissue morphology were also significantly improved. Conclusion:Compound Kushen Tang is considered as a no-vel therapeutic alternatives for the treatment of UC, which can reduce coloni inflammatory injury and ameliorate the colitis.
