Optimization of the Formula and Preparation Technology of Demethoxycurcumin Nano-structured Lipid Carriers
- VernacularTitle:脱甲氧基姜黄素纳米脂质载体的制备及处方工艺优化
- Author:
Wenting DAI
;
Jin CHEN
;
Zhengmin HE
;
Fengling WANG
;
Weidong CHEN
- Publication Type:Journal Article
- Keywords:
Demethoxycurcumin;
Nano-structured lipid carriers;
Formula and technology;
Orthogonal test
- From:
China Pharmacist
2016;19(10):1852-1855
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To screen the optimal formula and technology of demethoxycurcumin nano-structured lipid carriers. Meth-ods:The encapsulation efficiency as the main investigation index, the single factor exploration and orthogonal design were used to study the main factors affecting the quality of the nanoparticles. The optimal formula and technology were obtained. Results:The optimized parameters were as follows:the ratio of drug to lipid materials was 1 ∶40, the ratio of liquid lipid to total lipid materials was 10%, the amount of surfactants was 4% and the amount of lecithin was 2%. The prepared nanoparticles were spheric and regular. The size dis-tribution of the nanoparticles was narrow with the average particle size of 110nm and PDI of 0. 199. Conclusion:The optimized formula and technology of demethoxycurcumin nano-structured lipid carriers are stable and practicable,which provide reference for the further research of demethoxycurcumin.
