Clinical Observation of Three Kinds of Drug Regimens in the Treatment of Active Chronic Gastritis with Heli-cobacter Pylori Infection
10.6039/j.issn.1001-0408.2016.30.16
- VernacularTitle:3种用药方案治疗幽门螺杆菌感染活动性慢性胃炎的临床观察
- Author:
Zhi TAO
;
Mengmin WANG
;
Huifang LYU
- Publication Type:Journal Article
- Keywords:
Omeprazole;
Amoxycillin;
Clarithromycin;
Metronidazole;
Hp infection;
Active chronic gastritis;
Efficacy;
Safety
- From:
China Pharmacy
2016;27(30):4224-4226
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the Hp eradication situation and safety of three kinds of drug regimen in the treatment of active chronic gastritis with helicobacter pykori(Hp)infection. METHODS:150 active chronic gastritis patients with Hp infection were randomly divided into group A(50 cases),group B(50 cases)and group C(50 cases). Group A received Omeprazole enter-ic-coated capsule 20 mg,orally,twice a day+Amoxycillin capsules 1.0 g,orally,3 times a day+Clarithromycin tablet 0.5 g,oral-ly,once a day. Group B additionally received Colloidal bismuth pectin capsule 150 mg,orally,3 times a day. Group C received Omeprazole enteric-coated capsule 20 mg,orally,twice a day+Amoxycillin capsules 1.0 g,orally,3 times a day,1-5 d,Omepra-zole enteric-coated capsule 20 mg,orally,twice a day+ Clarithromycin tablets 0.5 g,orally,once a day+Metronidazole tablet 0.4 g,twice a day,6-10 d. All patients treated for 10 d. Effective rate of pain relief,relief time of pain and gastrointestinal symptoms, Hp eradication rate,recurrence after 12 follow-up and the incidence of adverse reactions in all groups were observed. RESULTS:Effective rate of pain relief and Hp eradication rate in group C were higher than group B,followed by group A,relief time of pain and gastrointestinal symptoms,recurrence rate in group C were lower than group B,which was lower than group A,with signifi-cant differences (P<0.05). The incidence of adverse reactions in group C was lower than group A and group B,with significant differences (P<0.05);while there was no significant difference in group A and group B (P>0.05). CONCLUSIONS:Taking omeprazole in stages combined with antibiotics can effectively relieve abdominal pains,shorten disease course,improve Hp eradica-tion rate,reduce long-term recurrence rate in the treatment of active chronic gastritis with Hp infection,with good safety.
