Preparation and in vitro Drug Release of Loxoprofen Sodium Sustained Release Pellets
- VernacularTitle:洛索洛芬钠缓释微丸的制备与体外释放度研究
- Author:
Jia YU
- Publication Type:Journal Article
- Keywords:
Loxoprofen sodium;
Sustained release pellets;
In vitro drug release;
Extrusion-spheronization technology
- From:
China Pharmacist
2016;19(10):1885-1888
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To prepare loxoprofen sodium sustained release pellets, and investigate the in vitro drug release behavior. Methods:Loxoprofen sodium loaded pellets were prepared by extrusion-spheronization technology, and the sustained release pellets were prepared with Eudragit RL 30D and Eudragit RS 30D as the sustained release coating film materials. The drug release behavior of loxoprofen sodium sustained release pellets in vitro was studied. Results:Eudragit RL 30D and Eudragit RS 30D with the ratio of 20 ∶80 was used as the sustained release coating film materials, the coating weight was 20%, the plasticizer content was 10%, and the content of talc was 45%. The in vitro release of loxoprofen sodium from the sustained release pellets was steady and entire in 12 h. Conclusion:The release behavior of loxoprofen sodium sustained release pellets is quite satisfactory. And the preparation technology may be used in the industrial production.
