Effect of Simvastatin on PWV-ABI and hs-CRP at the Early Stage of Hyperlipidemia Patients
- VernacularTitle:辛伐他汀对早期高脂血症患者脉搏波传导速度-踝臂指数、超敏C反应蛋白的影响
- Author:
Zhengcong DENG
;
Weihong WANG
;
Longqian LI
;
Xueqin QIN
- Publication Type:Journal Article
- Keywords:
Hyperlipidemia;
Simvastatin;
Pulse wave velocity;
Ankle-brachial index;
hs-CRP
- From:
China Pharmacist
2016;19(10):1894-1896
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the improving effect of simvastatin on the related indices of hyperlipidemia Patients at the early stage in Talimu oil field, and analyze the correlation between the pulse wave velocity ( PWV) and the other indicators. Methods:Totally 59 patients with hyperlipidemia in Talimu oil field hospital received simvastatin for 6 months. The systolic and diastolic blood pressure, high-sensitivity C-reactive protein (hs-CRP), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol ( LDL-C) , PWV and ankle-brachial index ( ABI) were assessed before and after the treatment. Moreo-ver, the correlation between PWV with the other factors were analyzed by a multiple linear regression method. Results: After the six-month treatment, the systolic and diastolic blood pressure showed no significant change;TC and LDL-C were significantly decreased ( P<0. 05), while HDL-C was increased. PWV was significantly decreased, and ABI was improved significantly (P<0. 05). The chan-ges in PWV were correlated with age and hs-CRP(P<0. 05 or P<0. 01). Conclusion:Simvastatin can significantly improve the relat-ed indices in the patients with hyperlipidemia, reduce PWV, increase ABI and decrease serum hs-CRP level. The determination of PWV and hs-CRP can predict the degree of atherosclerosis better, which plays an important role in the prevention of cardiovascular dis-eases.
