Efficacy Observation of Piperacillin/Tazobactam in the Treatment of Children with Congenital Megacolon Enteritis
- VernacularTitle:哌拉西林/他唑巴坦治疗小儿先天性巨结肠肠炎的疗效观察
- Author:
Weili XU
;
Lin LIU
;
Xiaofeng YANG
;
Suolin LI
- Publication Type:Journal Article
- Keywords:
Pipercillin/tazobactam;
Pediatric;
Congenital megacolon enteritis;
Enteritis
- From:
China Pharmacist
2016;19(10):1938-1941
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the curative effect and safety of piperacillin/tazobactam in the treatment of children with con-genital gegacolon enteritis. Methods:122 cases of congenital intestinal enteritis were randomly divided into two groups. The 72 pa-tients in the treatment group were treated with piperacillin/tazobactam sodium, and the 50 patients in the control group were treated with cefoperazone/sulbactam. The course of treatment was 714 days. The differences in C-reactive proteins, bolld leukocytes count and neutrophilic granulocyte percentage before and after the treatment, and the average treatment time in both groups were compared, and the efficacy and bacterial clearance were evaluated. Results:Between the treatment group and the control group, the differences in C-reactive protein, blood leukocytes count and neutrophilic granulocyte precentage before and after the treatment had no statistical signifi-cance(P>0. 05). The effective rete of the treatment group was 86. 11%,and that of the control group was 88%(P>0. 05). The pos-itive detection rate of pathogenic bacteria was 75. 41%, in which Escherichia coli was the first pathogenic bacteria. The bacterial clear-ance in the treatment group was 85. 96%, which was higher than that (80%) in the control group(P>0. 05). Conclusion:The effi-cacy of piperacillin/tazobactam in the treatment of children with congenital megacolon enteritis is more obvious with promising safety.
