Preparation Technology Optimization of Ketoconazole and Miconazole Nitrate β- Cyclodextrin Inclusion Compound
- VernacularTitle:酮康唑、硝酸咪康唑β-环糊精包合物的工艺优选
- Author:
Jin ZHOU
;
Wentao HUANG
- Publication Type:Journal Article
- Keywords:
Ketoconazole;
Miconazole nitrate;
β-Cyclodextrin;
Inclusion compound
- From:
China Pharmacist
2016;19(10):1956-1958
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To optimize the preparation technology of ketoconazole and miconazole nitrateβ-cyclodextrin inclusion com-pound. Methods: The weight ratio of β-cyclodextrin to ketoconazole, inclusion temperature and inclusion time as the testing factors, the optimal inclusion technology was screened by orthogonal experiments. Results:The optimum inclusion conditions were as follows:the weight ratio of β-cyclodextrin to ketoconazole was 8 ∶1, the inclusion temperature was 50℃, and the ultrasonic time was 50 min. Conclusion:The optimized β-cyclodextrin inclusion process is simple and convenient to carry out.
