Expression and significance of Slug in papillary thyroid carcinomas
10.3969/j.issn.1006-5725.2016.19.023
- VernacularTitle:Slug在甲状腺乳头状癌中的表达及其临床意义
- Author:
Xuedong ZHANG
;
Shichao CHEN
;
De JIAO
;
Hong HONG
;
Wenjuan WEN
;
Jinqiang YAN
- Publication Type:Journal Article
- Keywords:
Papillary thyroid carcinomas;
Slug;
Clinicopathology;
Prognosis
- From:
The Journal of Practical Medicine
2016;32(19):3197-3199
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical significance of Slug expression in papillary thyroid carci-noma(PTC). Methods Employed Ventana immunohistochemistry assay to determine the expression of Slug in 107 cases of PTC and para-tumorous normal tissue. The relationship with Slug expression in PTC and clinico-pathology data were also analyzed. Results Expression of Slug in PTC (65.4%, 70/107)and para-tumorous nor-mal tissue (14.0%,15/107)were statistically different (P < 0.001). Overexpression of Slug in PTC was signifi-cantly associated with capsular invasion and lymph node metastasis (P < 0.05). Conclusion Overexpression of Slug in PTC is associated with capsular invasion and lymph node metastasis , these may suggest some clinical significance of Slug expression in PTC in predicting lymph node metastasis and prognosis.
