Formula Optimization of Shengmai Dispersible Tablets by Uniform Design
- VernacularTitle:均匀设计法优化生脉分散片处方
- Author:
Hao DENG
;
Zhijun ZHU
;
Song GAO
;
Yingli LI
;
Yachao JIANG
;
Nannan ZHANG
- Publication Type:Journal Article
- Keywords:
Dispersible tablets;
Uniform design;
Preparation process
- From:
China Pharmacist
2016;19(10):1980-1983
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the formula and preparation technology parameters of Shengmai dispersible tablets. Methods:With the granulation status, disintegration time, friability, taste and and so on as the testing indices, the formula and preparation tech-nology of Shengmai dispersion tablets were optimized by uniform design. Results:The optimized formula of Shengmai dispersible tab-lets was as follows:25% extract powder, 58% MCC, 8% CCMC-Na, 4% CMS-Na, 2% L-HPC, 2% magnesium stearate and 1%sweetener. L-HPC and magnesium stearate were added after the granulation, and the tablet hardness was controlled at 25N. The opti-mized dispersible tablets could disintegrate uniformly within 3 min. Conclusion: The optimization of the prescription and preparation process parameters of Shengmai dispersing tablets is stable and reliable, and has good repeatability, and the process is feasible.
