Transplantation time and detection method of allo-HSCT and the DNA of the recipients and its significance ;in forensic medicine(
10.13618/j.issn.1001-5728.2016.05.008
- VernacularTitle:移植时间和检测方法与allo-HSCT受者的DNA嵌合率及法医学意义
- Author:
Chunli DING
;
Feng ZHAO
;
Xue ZHOU
;
Xuebo LI
;
Hao MENG
;
Qiang FANG
- Publication Type:Journal Article
- Keywords:
forensic biological evidence;
allo-HSCT;
chimeric rate;
transplantation time;
detection method
- From:
Chinese Journal of Forensic Medicine
2016;31(5):459-462
- CountryChina
- Language:Chinese
-
Abstract:
There were many factors that affect the chimerism of donor DNA, such as the type of disease, the treatment of the disease, the severity of the disease, the source of hematopoietic stem cells, HLA, GVHD, and so on. This paper mainly discussed the two factors that affect forensic science, including the posttransplantation intervals and sensitivity of the detection method. Forensic workers in forensic practice and paternity and individual identification of allo HSCT recipients, should pay attention to the time after transplantation and the detection method of sensitivity of chimerism. When female recipients received HSCT in the case of male donors, Y chromosome DNA of the donor can be detected from the recipient's hair follicles. The case of biological specimens from the crime scene can not only detect Y chromosome speciifc genetic markers, so as to avoid wrong identiifcation.
