Application of 18F-FDG/99mTc-MIBI dual-isotope SPECT and gated myocardial imaging in early diagnosis of diabetes-induced myocardial damage
10.3969/j.issn.1006-5725.2016.20.005
- VernacularTitle:18F-FDG和99mTc-MIBI双核素心肌代谢／灌注显像及门控心肌灌注显像在糖尿病心肌损害早期诊断中的应用
- Author:
Weixiao ZHANG
;
Dandan SHENG
;
Xiaofei XU
;
Cheng WANG
;
Lingling ZHOU
;
Yajie LIU
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
Cardiac damage;
18F-FDG/ 99mTc-MIBI;
Dual-isotope SPECT;
Early diagnosis
- From:
The Journal of Practical Medicine
2016;32(20):3303-3306
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the diagnostic value of 18F-FDG/ 99mTc-MIBI dual-isotope SPECT and gated myocardial imaging in early diagnosis of diabetes-induced myocardial damage. Methods 32 patients with diabetes and 26 healthy volunteers received 18F-FDG/ 99mTc-MIBI dual-isotope SPECT and gated myocardial imaging for assessing myocardial ischemia, viability status, and cardiac function. Results Myocardial perfusion abnormalitieswere observed in 47 regions on myocardial perfusion imagingin 21 of 32 (65.6%)patients with diabetes, showing perfusion/metabolism mismatched and suggesting viable myocardium. All the volunteers were normal on DISA. As compared with the normal control group, the positive rate of DISA in diabetic patients was significantly higher (P < 0.01). Left ventricular ejection fraction (LVEF) was (54.3 ± 7.2%) and (67.3±4.9%) respectively, the difference was statistically significant (P < 0.05). Conclusions 18F-FDG/ 99mTc-MIBI dual-isotope SPECT and gated myocardial imaging can assess myocardial ischemia ,viability and cardiac function in diabetic patients, and it is helpful for the early diagnosis of cardiac damage in patients with diabetes mellitus.
