Serum 25-hydroxyvitamin D level, chronic inflammation state and malnutrition in maintenance hemodialysis patients

VernacularTitle:维持性血液透析患者血25（OH）D水平与慢性炎症状态及营养不良的关系
Author: Lan HUANG ; Jin ZHOU ; Xiaoli WANG ; Yajuan ZHAO ; Guicai HU
Publication Type:Journal Article
Keywords: Hemodialysis; 25-hydroxyvitamin D; Chronic inflammation state; Malnutrition
From: The Journal of Practical Medicine 2016;32(20):3318-3320
CountryChina
Language:Chinese
Abstract: Objective To identify the relationship among serum 25-hydroxyvitamin D[25(OH)D] level, chronic inflammation state and malnutrition in maintenance hemodialysis (MHD) patients. Methods The serum 25 (OH)D level of 119 patients on MHD was detected. All the patients were divided into three groups according to the serum 25(OH)D level. Vitamin D deficiency: 25(OH)D ≤ 15 ng/mL, vitamin D insufficiency: 15 ng/mL <25(OH)D ≤ 30 ng/mL, vitamin D normal: 25(OH)D > 30 ng/mL. Inflammatory factor and nutritive index were compared among the three groups. Result The average of serum 25 (OH)D level was 3.4~45.3 ng/mL (22.5~14.8 ng/mL), and the prevalence of 25 (OH)D deficiency and insufficiency was 88.2%. Significant differences existed in age, inflammatory factor (IL-6, TNF-α, CRP) and nutritive index (Alb, PA, SGA) between 25(OH)D deficiency, insufficiency groups and normal group (P<0.05). Conclusion The serum 25(OH)D level is possibly related to the malnutrition in MHD patients. It may inhibit chronic inflammation state , in which it can promote state of nutrition of MHD patients.