Association of Apolipoprotein A5 (c.553G/T) gene polymorphism with hypertriglyceridemia of the Han Nationality in Zunyi
10.3969/j.issn.1006-5725.2016.20.029
- VernacularTitle:遵义汉族载脂蛋白A5（c．553G／T）基因多态性与高甘油三酯血症
- Author:
Xiao YU
;
Huayu DAI
;
Yezhong WANG
;
Zhengguang GENG
;
Zhimin ZHANG
- Publication Type:Journal Article
- Keywords:
Hypertriglyceridemia;
Apolipoprotein A5 gene;
c.553G/T polymorphism;
Zunyi Han nationality
- From:
The Journal of Practical Medicine
2016;32(20):3386-3390
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relativity between c.553G/T polymorphism in exon 4 of Apolipoprotein A5 gene and hypertriglyceridemia (HTG) in Zunyi Han Nationality. Methods c.553G/T polymorphism of 103 HTG patients and 165 healthy individuals were tested by polymerase chain reaction and restriction fragment length (PCR-RFLP) assay. The distributions of genotypes and allele frequencies in HTG patients and healthy group were analyzed between Zunyi population and others. Results The genotype frequency of the Apo A5 gene c.553G/T showed statistical difference between patients group and normal groups (P < 0.05). The distribution of ApoA5 c.553T gene in HTG was higher than the normal group significantly (P < 0.05), and it had effect on triglyceridemia level independently (OR = 15.768, 95%CI: 5.916 ~ 42.025, P < 0.001). In the normal Han nationality groups, gene frequency of Zunyi was lower than that in Taiwan, Jiangsu and Hubei (P < 0.05), but similar to that in Hunan and Xinjiang (P > 0.05). In HTG groups, gene frequency of Zunyi was similar to that in Jiangsu (P>0.05), but higher than that in Xinjiang (P<0.05) and lower than that in Taiwan (P > 0.05). Conclusion There is relativity between Apo A5 gene c.553G/T polymorphisms and HTG in Zunyi Han nationality and the differences vary across different areas. It could be an independent risk factor for HTG.
