Meta-analysis of Fasudil Hydrochloride Injection in the Treatment of Aneurysm Postoperative Cerebral Vasospasm
- VernacularTitle:法舒地尔注射液治疗动脉瘤术后脑血管痉挛的Meta分析
- Author:
Yu SUN
;
Qingchun ZHAO
;
Guobing SHI
;
Tianshu REN
;
Dasheng DANG
- Publication Type:Journal Article
- Keywords:
Fasudil hydrochloride;
Aneurysm;
Cerebral vasospasm;
Meta-analysis
- From:
China Pharmacist
2016;19(10):1902-1905
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the curative effect and safety of fasudil hydrochloride injection in the prevention and treatment of aneurysm postoperative cerebral vasospasm by meta-analysis. Methods: The randomized controlled trials were retrieved from PubMed, EMBASE, Cochrane Library, VIP, Wangfang, CNKI and so on. Meta-analysis was conducted using RevMan 5. 0 software. Results:Totally 418 reference studies were screened, from which 11 ones were chosen including 786 patients in all. In the treatment of cerebral vasospasm (CVS), there was no significant difference between the groups (OR=1. 56, 95%CI:0. 95-2. 58, P>0. 05). While in the prevention of CVS, the incidence rate of CVS in fasudil group was significantly lower than that in nimodipine group ( OR=0. 43, 95%CI:0. 23-0. 81, P=0. 008). However, the incidence rate of ADR in fasudile group was higher than that in nimodipine group (OR=0. 43, 95%CI:0. 25-0. 75,P=0. 003). Conclusion:In the prevention of CVS, fasudil may be better than nimodipine, while the incidence of ADR is higher.
