Relationship between leptin, lipid metabolic disorder and gestational diabetes mellitus
10.3969/j.issn.1006-5725.2016.19.005
- VernacularTitle:瘦素、脂代谢紊乱与妊娠期糖尿病的关系
- Author:
Jingfang LI
;
Yanqin FU
;
Suhe ZHANG
- Publication Type:Journal Article
- Keywords:
Gestational diabetes mellitus;
Leptin;
Blood lipid
- From:
The Journal of Practical Medicine
2016;32(19):3130-3132
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the relationship between and value of Leptin with disorder of lipid metabolism in gestational diabetes mellitus. Method Research objects are divided into three groups including GDM group, normal glucose tolerance group (NGT group), normal non-pregnant group. Blood lipid, fasting blood glucose, fasting insulin, serum leptin and placental leptin levels were detected and HOMA-IR was calculated. Result (1) Serum leptin, TC, TG, placental leptin and HOMA-IR in GDM group were higher than those of NGT group and TC, serum leptin and HOMA-IR of NGT group were higher than those of control group. There were statistical significances (P<0.05). (2)Serum leptin levels were positively correlated with BMI, HOMA-IR, TC and TG respectively (r = 0.593, 0.688, 0.722, 0.492 respectively, P < 0.05). Conclusion Leptin may cause lipid metabolism disorders, and together they participate in the pathogenesis of GDM. Maternal serum leptin level is expected to become an observation index of GDM.
