The study on the expression and clinical significance of APRIL in urothelial carcinoma
10.3969/j.issn.1006-5725.2016.19.031
- VernacularTitle:增殖诱导配体在膀胱尿路上皮癌中的表达及临床意义
- Author:
Wanli ZHAO
;
Sheng LIU
;
Min LIU
;
Xudong ZHOU
;
Pengyu SUN
;
Xian WANG
;
Jihong YANG
;
Xiaoli MA
- Publication Type:Journal Article
- Keywords:
Urothelial Carcinoma;
APRIL;
Up-expression
- From:
The Journal of Practical Medicine
2016;32(19):3227-3230
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of a proliferation-inducing ligand (APRIL) in urothelial carcinoma tissue and its clinical significance. Methods We investigated the expression of APRIL mR-NA in urothelial carcinoma tissue of 33 patients in urothelial carcinoma in Cangzhou Central Hospital from July 2013 to March 2015, Among of them, 23 cases of adjacent pericancerous tissues were detected by qRT-PCR. Immunohistochemistry and western blot were used to detect the APRIL protein expression level in urothelial carci-noma tissue and adjacent pericancerous tissues. We analyzed the relationship between APRIL expression and clinical pathology in patients with urothelial carcinoma by statistical methods. Results The qRT-PCR revealed that the expression of APRIL in urothelial carcinoma tissue was significantly higher than that in the adjacent peri-cancerous tissues (P < 0.05). Immunohistochemistry and western blot showed that the expression of APRIL in urothelial carcinoma tissue was higher than that in the adjacent pericancerous tissues. Correlation analysis found that the high expression of APRIL in urothelial carcinoma tissue was not significantly related to gender , age , size of tumor, lymph node metastasizing or not, and clinical stages (P > 0.05). Conclusion The APRIL is a high abnormal expression in urothelial carcinoma tissues , and maybe related to the occurrence and development of urothelial carcinoma.
