Efficacy of trofiban injected to coronary occlusion segment via a suction catheter for treatment of acute myocardial infarction
10.3969/j.issn.1006-5725.2016.18.017
- VernacularTitle:经抽吸导管冠脉闭塞段内注入替罗非班治疗急性心肌梗死
- Author:
Jianfa ZHENG
;
Hegui WANG
;
Bingfeng ZHOU
;
Yongsheng KE
;
Xiangyang BAN
;
Minmin FU
;
Bing WANG
;
Qinghe XU
- Publication Type:Journal Article
- Keywords:
Acute myocardial infarction;
Thrombus Suction Catheter;
Tirofiban
- From:
The Journal of Practical Medicine
2016;32(18):3004-3007
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of tirofiban injection in coronary artery occlusion by suction catheter on the opening time of the coronary artery occlusion , the improvement of the blood flow and the incidence of adverse events in 30 days. Methods A total of 97 patients with acute myocardial infarction in recent 4 years were included , whose culprit vessels were subtotal occlusion or total occlusion by angiography and were randomly divided into thrombus aspiration group (group A) and tirofiban injection in occlusion and thrombus aspiration group (group B). The opening time of the coronary artery, the improvement of the blood flow and the incidence of adverse events in 30 days were compared between two groups. Results The opening time of the coronary artery occlusion in group A was shortened when compared with group B but the blood flow arriving TIMI III grade in group B was shorter (P < 0.05). No-reflow incidence in group B was lower while the proportion of blood flow arriving TIMI III grade was higher than that in group A in early phase (P < 0.05). The incidence of adverse events in 30 days was decreased in group B when compared with group A ,but the difference wasn't statistically significant (P > 0.05). Conclusion Direct tirofiban injection in coronary artery occlusion could effectively shorten the opening time of the coronary artery occlusion reduce no-reflow incidence , and improve coronary perfusion but could not decrease the incidence of adverse cardiovascular events in 30 days.
