Mechanism of FTY720 on cardiovascular complications of diabetes mellitus
10.3969/j.issn.1006-5725.2016.20.002
- VernacularTitle:FTY720对糖尿病心血管并发症的干预作用及机制
- Author:
Ting WEN
;
Weimin DENG
;
Jianying ZENG
- Publication Type:Journal Article
- Keywords:
TypeⅠdiabetic;
FTY720;
Micro-cardiac vessels
- From:
The Journal of Practical Medicine
2016;32(20):3293-3295
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the mechanism of FTY720 on type Ι diabetic rats. Methods The typeⅠdiabetes rat model was established by feeding male SD rats with high energy urea and injecting into the abdominal cavity with low dose cephalosporins (STZ, 30 mg/kg). In the following, the treated rats were divided into two groups: model group and FTY720 group. Another group of untreated rats was assigned as normal control group. FTY720 group was given 1 mg/kg FTY720, the normal control group and model group was given the equal amount of water. Results The cardiac function of FTY720 group was recovered markeyly. FTY720 activated the expression of vascular endothelial cells S1P1 , diabetes and reduced the expessions of S1P3 and PKCβ Ⅱand it restored the migration ability of diabetes cardiovascular endothelial cell , as well as the abnormally elevated cardiovascular endothelial cells induced by high sugar permeability. Conclusion The S1P1 and S1P3 cut is an important reaction pathway to the complications of diabetes and cardiovascular dysfunction. FTY720 may reduce the damage to core blood vessels caused by diabetes , and pathological angiogenesis which functionally depends on the PKCβⅡ signaling pathways. Therefore, FTY720 may provide a potential therapy for cardiovascular function impaired by diabetes.
