Clinical significance of serum TK1 levels for patients with non-small-cell lung cancer undergoing chemotherapy
10.3969/j.issn.1006-5725.2016.17.017
- VernacularTitle:血清胸苷激酶1评估非小细胞肺癌化疗疗效的意义
- Author:
Renfei HUANG
;
Qian JIANG
;
Mengmeng JIN
;
Yin LIU
;
Ting DU
;
Yanbei ZHANG
- Publication Type:Journal Article
- Keywords:
Non-small-cell lung cancer;
Chemotherapy;
Serum TK1;
Dynamically monitor
- From:
The Journal of Practical Medicine
2016;32(17):2840-2843
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the dynamic change and its clinical significance of serum thymidine kinase 1 (STK1) in patients with non-small-cell lung cancer (NSCLC) when undergoing 4 cycles of chemotherapy. Methods We detected STK1 levels of 59 patients with NSCLC throughout 4 cycles of chemotherapy using Enhanced Chemiluminescence Western Blot and analyze its relationship with chemotherapy responses . Results STK1 levels with different chemotherapy regimens had no significant difference. STKK1 levels in patients with effective response were significantly lower after 4 cycles of chemotherapy. STK1 levels in patients with effective response were significantly lower than those in non-responders throughout 4 cycles of chemotherapy. The positive rates of STK1 in those with effective response were lower than those in non-responders after the last two cycles of chemotherapy. STK1 levels between lung squamous carcinoma and lung adenocarcinoma had no significant difference. Conclusion The detection of the changes of serum TK1 in patients with NSCLC undergoing chemotherapy is useful in evaluating the effect of chemotherapy and the later therapeutic schedule.
