The efficacy and safety of vidldagliptin combined with acarbose in treating type 2 diabetes

VernacularTitle:维格列汀联合阿卡波糖治疗2型糖尿病的疗效及安全性
Author: Rujia YE ; Guangyao WANG ; Xinghua WANG ; Xinyi SUN
Publication Type:Journal Article
Keywords: Type 2 diabetes; Vildagliptin; Acarbose; Curative effect
From: The Journal of Practical Medicine 2016;32(20):3312-3314
CountryChina
Language:Chinese
Abstract: Objective To observe the efficacy and safety of vildagliptin combined with acarbose in treating type 2 diabetes. Methods 78 patients with type 2 diabetes were divided into two groups to have additional vildagliptin combined with acarbose or acarbose combined with placebo. The clinical efficacy and adverse reactions after 12 weeks were investigated. Results In the treatment group, FBG, 2 h PG and HbA1C declined after treatment (P < 0.05) and FCP, 2 h CP, FINS and 2 h INS increased (P < 0.05). Compared with the control group, FBG and HbA1c in the treatment group were reduced and owever, FCP, 2 h CP, FINS and 2 h INS were increased more significantly (P < 0.05). There was no difference in the incidence of overall BMI between the two groups (P > 0.05). There were either liver and kidney damage (P > 0.05), nor hypoglycemia. Conclusion Vildagliptin combined with acarbose is superior to Acarbose combined with placebo , and it produced no more untoward effect.