Expression and clinical significance of androgen receptor in human epidermal growth factor receptor-2 enrich breast cancer
10.3969/j.issn.1006-5725.2016.17.021
- VernacularTitle:雄激素受体在Her-2过表达型乳腺癌中的表达及其临床意义
- Author:
Jie NI
;
Lijie SHEN
;
Junjie HUO
;
Man LI
;
Xi JIANG
;
Xuepin YAO
;
Xiangcheng ZHI
- Publication Type:Journal Article
- Keywords:
Breast neoplasm;
Androgen receptor;
Human epidermal growth factor receptor-2 enrich breast cancer
- From:
The Journal of Practical Medicine
2016;32(17):2854-2856
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of AR and its relationship with clinicopathological features in human epidermal growth factor receptor-2(Her-2) enrich breast cancer. Mehtods The expression of AR was detected by immunohistochemical staining in 102 patients with Her-2 enrich breast cancer. The relationship between AR expression and its clinicopathological characteristics was analyzed. Results The positive rate of AR expression was 75.5%. Patients in the positive group had a lower level of lymph nodes and Ki-67 value (P < 0.05). However, no significant differences of AR expression were observed in age, menopausal status, tumor size, histological grade, vessel invasion, P53 and PCNA (P > 0.05). Conclusion AR was highly expressed in Her-2 enrich breast cancer, which may be a potential target for treatment of Her-2 enrich breast cancer.