Expression of NAP in patients with acute myeloid leukemia
10.3969/j.issn.1006-5725.2016.17.024
- VernacularTitle:急性髓系白血病患者外周血中性粒细胞碱性磷酸酶的表达及意义
- Author:
Jibao QIN
;
Weibo BO
;
Jin YANG
- Publication Type:Journal Article
- Keywords:
Acute myeloid leukemia;
Neutrophil alkaline phosphatase;
G-CSF;
NE;
IL-8
- From:
The Journal of Practical Medicine
2016;32(17):2864-2866
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of NAP in patients with acute myeloid leukemia (AML). Methods Expression of NAP of peripheral blood was assessed by flow cytometry. The serum levels of G-CSF, NE and IL-18 in 53 patients with AML and 50 healthy controls were examined by ELISA. Results The expression of NAP in AML patients [1 159(563 ~ 2 033)AB/c] was decreased than that of healthy controls [1 862 (1 345 ~ 2 382)AB/c], (P < 0.05). The serum levels of G-CSF, NE and IL-8 from AML patients [34.36 (25.17 ~ 47.24) ng/L, 397.56 (324.63 ~ 563.84) pg/mL, 585.34 (403.61 ~ 866.54) pg/mL] were significantly lower than those of healthy controls[54.52(46.27 ~ 77.14) ng/L, 689.74(496.78 ~ 899.14) pg/mL, 832.36(625.17 ~ 998.24) pg/mL] (P < 0.05). The expression of NAP in AML patients was positively correlated with the serum level of G-CSF (r = 0.621, P = 0.007). Conclusions The decreased expression of NAP, G-CSF, NE and IL-8 in the peripheral blood with AML could speculated that neutrophils immune function in patients with AML was restrained.
