Effects of Dexmedetomidine on Renal Function of Patients after Valvular Heart Surgery
10.3969/j.issn.1006-5725.2016.20.044
- VernacularTitle:右美托咪定对心脏瓣膜置换术患者围术期肾功能的影响
- Author:
Zheng ZHANG
;
Jiang HE
;
Sha LI
;
Bo HE
;
Jun CAI
- Publication Type:Journal Article
- Keywords:
Dexmedetomidine;
Rheumatic heart disease;
Valvular heart surgery;
Renal function
- From:
The Journal of Practical Medicine
2016;32(20):3439-3442
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of dexmedetomidine on postoperative renal function of patients with rheumatic heart disease following valvular heart surgery. Methods Fifty patients following valvular heart surgery were randomized into experimental group and control group,with 25 cases in each group. The patients in experimental group receiveddexmedetomidine 0.5 μg/kg infusion 15min before induction, and then 0.5 μg/(kg·h) infused to the end of surgery, while those in control group received the same amount of saline in the same way. Blood from central venous was collected before surgery, at the end of surgery, 24 h and 48 h after surgery in order to detect Src, BUN and Cys C and the length of ICU duration was also recorded. Results Src and Cys C of the patients in both groups obviously elevated 24h after surgery when compared with pre-operation , while BUN elevated at both 24 h and 48 h after surgery(P < 0.05). Compared with those in control group, Src, BUN and Cys C were lower in experimental group ( P < 0 . 05 ) , and the length of ICU duration was shorter (P < 0.05). Conclusion Dexmedetomidine could improve the postoperative renal function after valvular heart surgery and lead to a better prognosis.
