Diagnostic value of T-SPOT.TB for tuberculous pleurisy in immunocompromised patients
10.3969/j.issn.1006-5725.2016.18.022
- VernacularTitle:T－SPOT.TB对免疫低下合并结核性胸膜炎患者的诊断价值
- Author:
Wenqing JIA
;
Ying LIU
- Publication Type:Journal Article
- Keywords:
tuberculous pleurisy;
immunocompromised;
T-SPOT.TB;
diagnosis
- From:
The Journal of Practical Medicine
2016;32(18):3023-3026
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical value of tuberculous infection of T cells spot test (T-SPOT. TB)for diagnosing tuberculous pleurisy in immunocompromised patients. Methods The sensitivities of T-SPOT. TB,ADA, TB-DNA and tuberculosis antibodies to tuberculous pleurisy in 54 immunocompromised patients were compared.Among these patients,22 were retested by T-SPOT. TB after 2 months anti-tuberculosis treatment. Spot forming cells(SFCs) were compared before and after treatment. Results The diagnostic sensitivity of T-SPOT.TB (79.63%)was significantly higher than those of ADA (64.81%),TB-DNA (48.15%)and tuberculosis antibodies (55.56%) (P<0.05).22 patients were retested by the T-SPOT.TB after anti-TB treatment (2 months), the results showed that the positive rate of T-SPOT.TB was 90.91%,not significantly than previous tests (P<0.05).Both ESAT-6 and CFP-10 specific SFCs decreased significantly compared with those before anti-TB treatment (t=2.728 and 2.400,P<0.05 respectively). Conclusions T-SPOT.TB assay has satisfactory sensitivity and could be used in diagnosis of tuberculous pleurisy in immunocompromised patients.
