Expression of ATRX in different central nervous system tumors and the usefulness in differential diagnosis
10.3969/j.issn.1006-5725.2016.18.023
- VernacularTitle:ATRX在不同类型中枢神经系统肿瘤中的表达及其在鉴别诊断中的意义
- Author:
Mingliang CHU
;
Zhuxue ZHANG
;
Yun ZHANG
;
Yingchun YANG
;
Hede SHEN
;
Wei YI
- Publication Type:Journal Article
- Keywords:
Central nervous system tumors;
ATRX
- From:
The Journal of Practical Medicine
2016;32(18):3026-3029
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of α-thalassemia/mental retardation syndrome X-linked (ATRX) in different central nervous system tumors and the meaningness in differential diagnosis. Methods Expression of ATRX protein was determined by immunohistochemistry in astrocytomas , oligodendrogliomas, glioblastomas, ependymomas and meningiomas. Results Positive expression levels of ATRX in astrocytomas were significantly lower than those in oligodendrogliomas,glioblastomas, ependymomas and meningiomas (all P <0.01). Conclusion The loss of ATRX was mainly occurred in astrocytomas, which could be as a astrocytoma marker in diagnosis.
