Progress in relationship between long non-coding RNAs and gastric cancer
10.3760/cma.j.issn.1006-9801.2016.10.016
- VernacularTitle:长链非编码RNA与胃癌关系的研究进展
- Author:
Zhiwei ZHAO
;
Yan SONG
;
Daxun PIAO
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Long non-coding RNAs;
Epigenetics
- From:
Cancer Research and Clinic
2016;28(10):709-713
- CountryChina
- Language:Chinese
-
Abstract:
Long non-coding RNAs (lncRNAs) are a group of regulatory and non-coding RNA molecules which are longer than 200 nucleotides. They are involved in a variety of biological processes such as cell proliferation, differentiation and apoptosis mainly by regulation of gene expression at various levels, including epigenetics, transcription and post-transcription. The evidence has demonstrated that many lncRNAs are dysregulated and closely related to tumorigenesis, progression and prognosis in gastric cancer. Based on an introduction to lncRNAs and the domestic and foreign research status, this review summarizes the function, regulatory mechanisms, potential diagnostic and therapeutic values of lncRNAs in gastric cancer.
