Changes and significance of heart-type fatty acid-binding protein and N terminal probrain natriuretic peptide in sepsis patients with myocardium injury
10.3969/j.issn.1006-5725.2016.17.022
- VernacularTitle:心型脂肪酸结合蛋白和N-末端脑钠肽前体在脓毒症心肌损伤中的变化及意义
- Author:
Hongna QI
;
Jianjun ZHANG
;
Jiaqi HE
;
Weizhan WANG
;
Yaqin LI
- Publication Type:Journal Article
- Keywords:
Sepsis;
Myocardium injury;
Heart-type fatty acid binding protein;
N terminal probrain natriuretic peptide
- From:
The Journal of Practical Medicine
2016;32(17):2857-2860
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical value of heart-type fatty acid-binding protein ( H-FABP) and N terminal probrain natriuretic peptide (NT-proBNP) in sepsis patients with myocardium injury. Methods 118 sepsis patients were included as survivor group (68 cases) and death group (50 cases) according to their prognosis outcome. 50 healthy people were selected as control group. Creatase, H-FABP, NT-proBNP, APACHEⅡscore and 28 day morbidity of control group and sepsis patients were assessed at 1 h, 6 h after admission by physical examination . Results At 1 h after admission , APACHEⅡscore , H-FABP and NT-proBNP level in sepsis patients were significantly higher than control group (P < 0.05); APACHEⅡscore, H-FABP, NT-proBNP and cTnI level at 6 h after admission were higher than that at 1 h (P < 0.05); APACHEⅡscore, H-FABP and NT-proBNP level in death group were higher than survivor group at 1, 6 h after admission (P < 0.05), cTnI level at 6 h after admission was higher in death group (P < 0.05). Futhermore, H-FABP, NT-proBNP and cTnI at 6 h after admission were positively correlated with each other (both P < 0.05). At 6 h after admission , H-FABP showed a better predictive value of 28-day mortality than NT-proBNP and APACHEⅡscore (P < 0.05). Conclusion H-FABP and NT-proBNP may suggest important significance in early diagnosis and prognosis prediction of sepsis patients with myocardium injury.
