Systematic Evaluation onYupingfeng Granules Combined with Western Medicine in the Treatment of Children with Recurrent Respiratory Tract Infections
10.3969/j.issn.1005-5304.2016.11.011
- VernacularTitle:玉屏风颗粒联合西药治疗儿童反复呼吸道感染系统评价
- Author:
Shanshan ZHAO
;
Kuo LIU
;
Jing LI
;
Junyan SHAO
- Publication Type:Journal Article
- Keywords:
children with recurrent respiratory tract infection;
Yupingfeng Granules;
immune function;
systematic evaluation
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2016;23(11):42-45
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate clinical efficacy ofYupingfeng Granules combined with western medicine for children with recurrent respiratory tract infection (RRTI).Methods CNKI, VIP, WANFANG DATA, SinoMed, PubMed, Embase, and Cochrane Library were searched for the randomized controlled trials (RCTs) that investigated the clinical and immune effects ofYupingfeng Granules in children with RRTI from inception to October 2015. Two researchers independently screened studies according to the inclusion and exclusion criteria, extracted data and evaluated the methodological quality of included studies. Then Meta analysis was performed through the software RevMan 5.3.Results A total of 8 articles involving 550 patients were included. The results of Meta analysis showed effective rate ofYupingfeng Granules combined with western medicine for children with RRTI [OR=4.16, 95%CI (2.49, 6.95),P<0.000 01], IgA level [MD=0.52, 95%CI (0.26, 0.78),P<0.000 1], IgG level [MD=2.75, 95%CI (1.25, 4.25),P=0.000 3], CD4+ level [MD=6.15, 95%CI (4.76, 7.54),P<0.000 01], CD4+/CD8+ level [MD=0.36, 95%CI (0.25, 0.47),P<0.000 01]. All of the above were superior to single western medicine treatment. There was no statistical significance in levels of IgM and CD8+(P>0.05). ConclusionYupingfeng Granules combined with western medicine can improve effective rate, antibody level and T-cell level in the treatment of children with RRTI. The overall clinical efficacy is better than single western medicine treatment. However, RCTs with large samples, multiple centers and high quality are needed for further verification.
