Effects of Volatile Oil of Angelicae Sinensis Radix on Blood Pressure and Vascular Inflammatory Response in Hypertensive Rat Models
10.3969/j.issn.1005-5304.2016.11.017
- VernacularTitle:当归挥发油对高血压模型大鼠血压及血管炎症反应的影响
- Author:
Beiyin LIU
;
Chengke WEI
;
Yingdong LI
- Publication Type:Journal Article
- Keywords:
volatile oil of Angelicae Sinensis Radix;
hypertension;
inflammatory cytokines;
rats
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2016;23(11):71-74
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of volatile oil of Angelicae Sinensis Radix on blood pressure and related inflammatory cytokines of hypertensive rat models; To investigate the action mechanism of regulating the blood pressure.Methods Wistar male rats were fed withL-NNA to establish hypertensive rat models. Hypertensive rats were randomly divided into normal control group, model group, positive medicine group, volatile oil of Angelicae Sinensis Radix high- and low-dose groups, with 5 rats in each group. Each medication group was given relative medicine for gavage for 8 weeks. Non-invasive blood pressure measurement system was used to observe the systolic pressure of tail artery of rats before and after medication; the levels of ET-1, CRP, and VCAM-1 in serum were detected by the method of ELISA; RT-PCR was used to measure CRP mRNA of heart.Results The levels of systolic blood pressure, ET-1, VCAM-1, CRP and CRP mRNA in model group were significantly higher than those of normal group (P<0.05,P<0.01); Compared with model group, the levels of ET-1, VCAM-1, CRP and CRP mRNA in model group significantly decreased (P<0.05, P<0.01).Conclusion Volatile oil of Angelicae Sinensis Radix can inhibit vascular inflammatory response and then realize the effects of regulating blood pressure.
