Optimization for Preparation Technology ofCangai Volatile Oil Dextrin Inclusion Compound/in situ Nasal Thermosensitive Gel by Central Composite Design-response Surface Method
10.3969/j.issn.1005-5304.2016.11.021
- VernacularTitle:星点设计-效应面法优化苍艾油包合物-鼻用温敏原位凝胶制备工艺
- Author:
Qiuyan HUANG
;
Lei XIONG
;
Hongmei WANG
;
Bojun CHEN
;
Yunshu MA
;
Shujun KONG
;
Hui WANG
- Publication Type:Journal Article
- Keywords:
Cangai volatile oil;
dextrin inclusion compound;
in situ nasal thermosensitive gel;
central composite design-response surface method
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2016;23(11):86-89
- CountryChina
- Language:Chinese
-
Abstract:
Objective To optimize the preparation technology ofCangai volatile oil dextrin inclusion compound/ in situ nasal thermosensitive gel by the central composite design-response surface method.Methods In the design, the investigation factors were the amounts of poloxamer 407 and poloxamer 188, and the evaluation index was the gel temperature. Quadratic models were used to evaluate the mathematic relation between the evaluation index and two investigation indexes to identify the optimum prescription, and then the optimum prescription was verified. Results According to the quadratic models, it was found that there was reliable quantitative relation between the evaluation index and two investigation indexes, among which the optimum dosage was 19.37% for poloxamer 407 and 2.73% for poloxamer 188.Conclusion The optimum model ofCangai volatile oil dextrin inclusion compound/ nasal thermosensitive gel can be obtained from central composite design-response surface method based on quadratic models. This method is reliable and feasible, which can realize the prescription optimization of the in situ gel.
