Bleeding risk of short-term intensive statin therapy after coronary artery bypass grafting
10.3969/j.issn.1005-6483.2016.10.008
- VernacularTitle:冠状动脉旁路移植术后短期内应用强化他汀对患者出血风险的研究
- Author:
Yu SHI
;
Xuegang LIU
- Publication Type:Journal Article
- Keywords:
intensive statin therapy;
coronary artery bypass grafting;
maximum platelet ag-gregation rate;
platelet aggreation inhibition rate;
the risk of bleeding
- From:
Journal of Clinical Surgery
2016;24(10):750-752
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the bleeding risk of short-term intensive statin therapy after coronary artery bypass grafting. Methods A total of 240 patients treated with coronary artery bypass grafting were randomly divided into group A(experimental group)and group B(control group). All pa-tients were normalized to conventional treatment and they were given low molecular weight heparin for an-ticoagulant therapy during the perioperative period. Patients in group A were given 40 mg of atorvastatin before surgery,and 40 mg of atorvastatin every night for one month after the surgery. Patients in group B were given 10 mg of atorvastatin every night during the treatment. One month after the operation,platelet aggregation rate and bleeding events of patients were compared. Results There were significant differ-ences in maximum platelet aggregation rate[(14. 5 ± 3. 7)% vs(38. 1 ± 7. 4)% ,P < 0. 05],inhibition rate of platelet aggregation[(79. 5 ± 4. 3)% vs(50. 8 ± 10. 2)% ,P < 0. 05],and incidence of postopera-tive bleeding[27. 5% vs 12. 5% ,P < 0. 05]between group A and B,respectively. Conclusion Short-term intensive statin therapy can increase the bleeding risk after coronary artery bypass grafting.
