Research progress on molecular regulatory effects of vitamin D on osteogenic differentiation of bone marrow stromal cells
10.3969/j.issn.1001-1978.2016.10.002
- VernacularTitle:维生素D对骨髓基质干细胞成骨分化的分子调控研究进展
- Author:
Yao ZHANG
;
Xiaoli LI
;
Yan ZHANG
- Publication Type:Journal Article
- Keywords:
vitamin D;
1,25(OH)2D3;
marrow stromal cells;
molecular regulation;
signaling pathway;
osteogenic differentia-tion
- From:
Chinese Pharmacological Bulletin
2016;32(10):1337-1340
- CountryChina
- Language:Chinese
-
Abstract:
Marrow stromal cells ( MSCs) , component of the mar-row stroma, play an important role in the growth of bone and metabolic balance. This paper mainly summarizes and reviews the molecular regulaory effects of vitamin D and its active form 1, 25 dihydroxy vitamin D3[1,25(OH)2D3] on the osteogenet-ic differentiation of MSCs by Wnt signaling pathway, Wnt5a/ROR2 axis, BMP/TGF-β/Samd signaling pathway and ROS/ERK signaling pathway, so as to clarify the molecular signaling pathway through which vitamin D regulates MSCs metabolically.
