Research progress on transport mechanism of amyloid beta-peptides across blood-brain barrier
10.3969/j.issn.1001-1978.2016.10.005
- VernacularTitle:β淀粉样蛋白跨血脑屏障转运机制研究进展
- Author:
Haijing ZHANG
;
Chunhui ZHAO
;
Wensheng ZHANG
- Publication Type:Journal Article
- Keywords:
amyloid beta-peptides;
Alzheimer ’ s Disease;
blood-brain barrier;
transport;
receptor for advanced glycation end-products;
low-density lipoprotein receptor-related protein
- From:
Chinese Pharmacological Bulletin
2016;32(10):1348-1352
- CountryChina
- Language:Chinese
-
Abstract:
Amyloid beta-peptides ( Aβ) is the key pathological feature of Alzheimer’s Disease (AD). Various factors contrib-ute to the accumulations of Aβ in the brains of patients. Among them, blood-brain barrier ( BBB) plays a crucial role in trans-porting Aβ between the brain and the bloodstream while this transfer function is mediated by the receptor of Aβon BBB. The abnormality of Aβ transport and related receptor expression can be detected in the brains of patients with AD, resulting in an un-usual increase in Aβlevels unusually increased . This review e-laborates the structure and function of BBB, the transport of Aβand the expression and transport mechanism of the related recep-tor, as well as summarizes the possible clearance strategy of Aβacross the BBB.
