Research progress on neuroprotective effects of vitexin and its mechanisms
10.3969/j.issn.1001-1978.2016.10.006
- VernacularTitle:牡荆素的神经保护作用及机制研究进展
- Author:
Lina MAO
;
Qing ZHU
;
Junxu LI
- Publication Type:Journal Article
- Keywords:
vitexin;
neuroprotection effects;
mechanisms;
An-algesia;
Receptors;
Review
- From:
Chinese Pharmacological Bulletin
2016;32(10):1353-1356
- CountryChina
- Language:Chinese
-
Abstract:
Vitexin, a natural flavonoid compound, has extensive pharmacological activity. In recent years, many studies have re-vealed that vitexin has significant protective effects on central nervous system and peripheral nervous system, including anti-memory impairment, anti-epilepsy, anti-ischemic hypoxic brain damage, anti-depression, analgesia, etc. Vitexin exerts neuro-protective effects through the mechanisms of multiple pathways and multi-targets, such as reducing free radical level, inhibiting neuronal apoptosis, modulating inflammatory factors and related pathways, and regulating neurotransmitters and related recep-tors. This review mainly discusses the neuroprotective effects of vitexin and its underlying mechanisms.
