The Trend of Eradication Rates of First-line Triple Therapy for Helicobacter pylori Infection: Single Center Experience for Recent Eight Years.
- Author:
You Sik CHOI
1
;
Jae Hee CHEON
;
Jong Yeul LEE
;
Sang Gyun KIM
;
Joo Sung KIM
;
Nayoung KIM
;
Dong Ho LEE
;
Jung Mogg KIM
;
Hyun Chae JUNG
;
In Sung SONG
Author Information
1. Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea. hyunchae@plaza.snu.ac.kr
- Publication Type:Original Article ; English Abstract
- Keywords:
Helicobacter pylori;
First-line regimen;
Eradication rates
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Amoxicillin/therapeutic use;
Anti-Bacterial Agents/therapeutic use;
Clarithromycin/therapeutic use;
Drug Therapy, Combination;
Female;
Helicobacter Infections/*drug therapy;
*Helicobacter pylori;
Humans;
Male;
Metronidazole/therapeutic use;
Middle Aged;
Retrospective Studies;
Treatment Outcome
- From:The Korean Journal of Gastroenterology
2006;48(3):156-161
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: The prevalence of antibiotic resistance in Helicobacter pylori (H. pylori) infection has been reported to be increasing. However, the recent trend of eradication rates of H. pylori using first-line triple regimens has been rarely issued. Therefore, we aimed to determine the trend of H. pylori eradication rates in single center for recent eight years. METHODS: From January 1998 through October 2005, H. pylori eradication rates in 525 patients with H. pylori-positive peptic ulcer disease who received one-week triple regimens were retrospectively evaluated according to years, regimens, and ulcer locations. RESULTS: The overall H. pylori eradication rate was 78.7%. Yearly eradication rates from the year 1998 to 2005 were 83.7%, 80.4%, 81.4%, 78.8%, 75.3%, 77.6%, 78.9% and 77.6% consecutively by per-protocol analysis, However, no definite evidence of decreasing tendency of eradication rate was seen during the past eight years (p=0.419). Furthermore, there was no significant difference in the eradication rates according to the ulcer locations and regimens. CONCLUSIONS: Although it is found that there is no definite statistical evidence of decreasing trend for H. pylori eradication rate during past eight years, those for recent 5 years were lower than 80%, which suggests that we should scrutinize the trend of first-line H. pylori eradication rate, and concern for the expected lower rates in the near future.
