Difference in antimicrobial susceptibility of common clinical pathogens to different ratios of cefoperazone/sulbactam antimicrobial disks
10.3969/j.issn.1671-9638.2016.10.006
- VernacularTitle:临床常见分离菌对不同配比头孢哌酮/舒巴坦的药敏差异
- Author:
Lian CHEN
;
Qianjun YE
- Publication Type:Journal Article
- Keywords:
cefoperazone/sulbactam;
extended-spectrum β-lactamase;
ESBLs;
Enterobacteriaceae;
imipenem-re-sistant Acinetobacter baumannii;
disk diffusion method;
drug resistance;
drug resistance,microbial;
rational antimicrobial use
- From:
Chinese Journal of Infection Control
2016;15(10):744-747
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the antimicrobial resistance of common clinical pathogens to antimicrobial disks containing different ratios of cefoperazone/sulbactam,so as to provide basis for rational application of cefoper-azone/sulbactam in clinic.Methods 1 141 pathogens isolated from clinical specimens in a hospital in the first half year of 2014 were collected,disk diffusion method was adopted to detect antimicrobial activity of two kinds of cef-operazone/sulbactam disks (70/35 μg and 75/75 μg).Results Of 1 141 pathogenic strains,675 (59.16%)were En-terobacteriaceae,447 (39.18%)were non-fermentative bacteria,and 19 (1 .66%)were other gram-negative bacilli. Resistance rates of pathogens to 70/35μg and 75/75 μg cefoperazone/sulbactam antimicrobial disks were as follows:extended-spectrumβ-lactamases(ESBLs)-producing Escherichia coli (n=221)were 7.69% and 2.26% respective-ly,ESBLs-producing Klebsiella pneumoniae (n=92)10.87% and 3.26% respectively,imipenem-resistant Acineto-bacter baumannii (IRAB,n=295)54.92% and 11 .19%respectively;there were significant differences in antimicrobial activity between two ratios of antimicrobial disks(P <0.05).While antimicrobial resistance rates of ESBLs-negative Enterobacteriaceae (Escherichia coli ,n = 135;Klebsiella pneumoniae ,n =98),imipenem-sensitive Acinetobacter baumannii (ISAB,n=51),Pseudomonas aeruginosa (n=48 ),and Stenotrophomonas maltophilia (n=22)were not significantly different (all P >0.05).Conclusion Antimicrobial activity of two different ratios of cefoperazone/sulbactam antimicrobial disks to ESBLs-producing Enterobacteriaceae and IRAB is different,attention should be paid to ratios of cefoperazone/sulbactam during the treatment ,so as to achieve the desired therapeutic effect.