The value of different methods for prevention of venous thromboembolism for patients undergoing laparoscopic gynecological surgery
10.3969/j.issn.1671-8348.2016.30.020
- VernacularTitle:不同方法预防妇科腹腔镜手术患者静脉血栓栓塞的应用价值
- Author:
Jun WANG
- Publication Type:Journal Article
- Keywords:
laparoscope;
thromboembolism,venous;
prevent;
gynecologic surgical procedure;
heparin,low-molecular-weight;
Salvia miltiorrhiza
- From:
Chongqing Medicine
2016;45(30):4240-4242
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical value of different methods for prevention of venous thromboembolism (VTE) for patients undergoing laparoscopic gynecological surgery with high risk factors .Methods Prospectively case controlled study was performed in 178 patients underwent laparoscopic gynecological surgery with high risk factors at the No .152 Central Hospital of PLA from January 2013 to October 2014 .All patients were divided into group A ,B and C .A total of 64 cases in group A received subcutaneous injection of LMWH (5 000 U ,once a day) at 12 hours after operation .A total of 64 cases in group B were treated with LMWH (2 500 U ,once a day) combined with Salvia miltiorrhiza(20 mL ,once a day) .A total of 50 cases in group C did not treated with prophylactic use of these drugs .The incidence of deep venous thrombosis(DVT) ,postoperative bleeding in and co‐agulation changes were recorded and compared in the three groups .Results All patients were successfully operated with laparosco‐py ,among them ,7 cases were complicated with DVT and 9 cases were complicated with postoperative bleeding .The incidence of postoperative DVT in group A ,B and C was 0 ,1 .6% and 12 .0% respectively ,the differences were statistically significant in group A and B compared with group C ,respectively (P<0 .05) .The incidence of postoperative bleeding group A ,B and C was 9 .4% , 3 .1% and 2 .0% respectively ,the differences were statistically significant in group A compared with group B and C (P<0 .05) .Af‐ter operation ,the platelet count in group A decreased ,however ,that in group B and C changed little .The platelet count in group A was statistically different compared with group B and C (P< 0 .05) .The plasma activated partial thromboplastin time and pro‐thrombin time in group A and B were prolonged ,the differences were statistically significant in group A and B compared with group C (P<0 .05) .Conclusion Early injection of LMWH after laparoscopic gynecological surgery in patients with high risk factors can significantly reduce the incidence of VTE ,LMWH combined with Salvia miltiorrhiza could improve security of anticoagulation with‐out increasing the risk of postoperative bleeding .
