Dyslipidemia in chronic renal failure patients with hypertension
- Author:
Dung Thi Kim Dinh
;
Loi Doan Do
- Publication Type:Journal Article
- Keywords:
chronic renal failure;
hypertension;
dyslipidemia
- MeSH:
chronic renal failure;
hypertension;
dyslipidemia
- From:Journal of Medical Research
2008;54(2):24-29
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Background: Hypertension is one of the most common complications in chronic renal failure (CRF) patients. Dyslipidemia in primary hypertension has been considered a risk factor of cardiovascular diseases and progression of CRF. Objectives: To determine lipid disorders CRF patients with hypertension and the correlations between lipid disorders and blood pressure level in CRF patients. Subjects and method: The descriptive cross-sectional study involved 107 CRF patients under 45 years old, who had preservative treatments and were monitored at Bach Mai Hospital from 2000 to 2003. They were divided into 2 groups: hypertension (n=78; 72.9%) and nonhypertension (n=29, 27.1%). Results: In comparison with nonhypertension group, patients in the hypertension group had higher level of serum creatinine (877.7+/-597.1 vs. 587.6+/-381 micromol/L, p< 0.01), total cholesterol (5.35+/-1.34 vs. 4.81+/-1.23 mmol/L, p< 0.05), ApoB (1.07+/-0.34 vs. 1.00+/-0.32 g/L) and CT/HDL-C ratio (5.33+/-2.2 vs. 4.9+/-1.4). In the hypertension group, 25.6% patients had the total cholesterol >=6.2 mmol/L, significantly higher than those in the nonhypertension group (p< 0.05), and the prevalence of abnormal level of LDL-C and ApoB increased with the grade of CRF. Patients with grade III of hypertension had severe dyslipidemia: hypercholesterolemia, hyperglyceridemia, increased LDL-C and ApoB, and CT-HDL-C ratio >5. Among them, 92.1% had lipoprotein disorders. Conclusion: Increased total cholesterol accounted for 25.6% patients of hypertension group. Prevalence of patients with disorders of LDL-C and ApoB were high in hypertension group, and increased with the grade of CRF. Lipoprotein disorders were increased with the grade of hypertension.
