Comparison of the hemostatic effect of total knee arthroplasty in intravenous and intra-articular injection of tranexamic acid
10.3969/j.issn.1671-8348.2016.30.023
- VernacularTitle:全膝关节置换中静脉和局部应用氨甲环酸的止血效果对比
- Author:
Haoran WANG
;
Jinbo DONG
;
Jianghua LI
;
Jian YANG
;
Weiguo ZHU
;
Jianhua SUN
;
Bin HE
- Publication Type:Journal Article
- Keywords:
total knee arthroplasty;
tranexamic acid;
intravenous;
intra articular injection;
amount of blood loss
- From:
Chongqing Medicine
2016;45(30):4249-4251
- CountryChina
- Language:Chinese
-
Abstract:
Objective To find a more suitable approach for the application of tranexamic acid(TXA)on total knee arthroplas‐ty (TKA) .Methods Totally 60 patients who met the inclusion criteria from January 2014 to August 2015 in the First Affiliated Hospital of Shihezi University were selected and divided into two groups according to the different route of administration .Group A (n=30) was intravenously injected with 100 mL TXA ,and group B(n=30) was locally injected with 100 mL TXA .Three hours drainage tubes occlusion were carried out after operation in the two groups .The intraoperative and postoperative dominant blood loss ,hidden blood loss indexes and the amount of total blood loss were recorded ,and coagulation indexes and D‐2 polymer were reg‐ularly monitored ,the incidence of thrombosis and postoperative adverse events were also observed .Results The amount of total blood loss in group B[(895 .41 ± 239 .02)mL] was lower than that in group A[(1 020 .89 ± 210 .83)mL] ,and the difference was statistically significant (P<0 .05);the total drainage volume in group B[(294 .33 ± 54 .25) mL] was lower than that in group A [(373 .33 ± 48 .02)mL] ,and the difference was statistically significant (P<0 .05) .After operation ,there was no significant differ‐ence between the two groups in coagulation indexes ,D‐2 polymer and the amount of hidden blood loss (P>0 .05) .No blood trans‐fusion ,symptomatic deep venous thrombosis and fatal pulmonary embolism occurred in the two groups .Conclusion The hemostatic effect of local application of TXA is better than that of intravenous injection in patients′initial TKA .
