Effects of Glutamine Dipeptide on Neurological and Gastrointestinal Function of Severe Organophosphate Poisoning Patients
10.6039/j.issn.1001-0408.2016.29.23
- VernacularTitle:丙氨酰谷氨酰胺对重症有机磷中毒患者神经和胃肠功能的影响
- Author:
Wubin WEN
;
Hong LI
;
Yuhua WANG
;
Shenjie ZHANG
;
Erni LI
;
Junhui WANG
;
Hui GAO
- Publication Type:Journal Article
- Keywords:
Severe organophosphate poisoning;
Glutamine dipeptide;
Gastrointestinal function;
Neurological function
- From:
China Pharmacy
2016;27(29):4103-4105
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effects of glutamine on neurological and gastrointestinal function of severe organo-phosphate poisoning patients. METHODS:46 patients with severe organic phosphorus poisoning in our hospital were enrolled and ran-domly divided into control group and observation group,with 23 cases in each group. Control group was given antidote atropine,en-ergy recovery agent pralidoxime chloride,blood perfusion and other symptomatic treatment. Observation group was additionally given Glutamine dipeptide injection 0.5 g/kg,ivgtt,qd,on the basis of control group. Both groups received the treatment for consecutive 3 d. The time of poisoning symptom disappearance,the time of blood cholinesterase recovery,hospitalization time,neurological and gastrointestinal function indexes were compared between 2 groups. RESULTS:The time of poisoning symptom disappearance,the time of blood cholinesterase recovery and hospitalization time of observation group were significantly shorter than those of control group,with statistical significance (P<0.05). After treatment,serum diamine oxidase and lactulose/mannitol of observation group were significantly lower than those of control group,while the serum content of citrulline was higher than in control group,with sta-tistical significance (P<0.05). After treatment,MCV and SCV of observation group were significantly higher than those of control group,while F wave latency was significantly shorter than control group,with statistical significance(P<0.05). CONCLUSIONS:Glutamine dipeptide is helpful to promote remission,improve gastrointestinal and neurological function.
