Analysis of 108 Cases of Adverse Drug Reactions Induced by Ticagrelor in Our Hospital

VernacularTitle:我院替格瑞洛致不良反应108例分析
Author: Li XIE ; Wenying ZHANG
Publication Type:Journal Article
Keywords: Ticagrelor; Adverse drug reaction; Monitoring; Analysis
From: China Pharmacy 2016;27(29):4085-4087
CountryChina
Language:Chinese
Abstract: OBJECTIVE:To explore the general regulation and characteristics of adverse drug reactions(ADR)induced by ti-cagrelor,and provide reference for clinical rational drug use. METHODS:672 patients received ticagrelor in our hospital from Dec. 2013 to Jun. 2015 were followed-up,and the situation was analyzed and summarized after taking drug. RESULTS:In the 672 patients,78(11.6%)patients sutfered from 108 cases of ADR,the ratio of male to female was 5.5∶1,there was statistical signifi-cance (P<0.05);patients mostly aged 51-60 years (37.2%);the mainly involved organs/systems were respiratory system (41.7%),and skin and its appendages (38.0%),the main clinical manifestations were minor bleeding (78.7%),dyspnea (17.6%) and bradycardia (2.8%);no severe ADR was found. CONCLUSIONS:Ticagrelor had good safety and tolerability,but due to its shorter time to market in China and absense of evidence-based medicine for large-scale clinical trials in Asian population, clinic should strengthen medication monitoring to reduce the ADR and ensure drug safety.