Practice of Clinical Pharmacists Participating in Anti-infective Treatment for A Patient with Tropical Candi-demia
10.6039/j.issn.1001-0408.2016.29.42
- VernacularTitle:临床药师参与1例热带念珠菌血症患者抗感染治疗的实践
- Author:
Xiayan XU
;
Hongyi LIANG
;
Bo JI
;
Jin YUAN
- Publication Type:Journal Article
- Keywords:
Clinical pharmacists;
Candidemia;
Candida tropicalis;
Caspofungin;
Contradiction
- From:
China Pharmacy
2016;27(29):4158-4160
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the role of clinical pharmacists participating in drug therapy for patients with severe infec-tions. METHODS:Clinical pharmacists participated in drug treatment for a patient with tropical candidemia and assisted physicians to adjust anti-infective treatment plan. According to the results of blood culture,clinical pharmacists suggested Piperacillin sodium and tazobactam sodium for injection 3.75 g,ivgtt,q8 h+Caspofungin acetate for injection 50 mg (initial dose of 70 mg),ivgtt, qd,for symptomatic treatment;increased the daily dose of Caspofungin acetate for injection to 50 mg,ivgtt,bid due to plasma ex-change;Caspofungin acetate for injection 50 mg,ivgtt,qd+Amphotericin B for injection 0.1 mg/kg,ivgtt,qd for anti-infective plan due to the possible“contradiction”of echinocandins;closely monitored ADR,such as allergy,erythra,renal function injury. RE-SULTS:Physicians adopted the suggestions of clinical pharmacists,vital sign of patient kept stable,and tropical candidemia was not detected in the blood culture;the patient was transferred to general ward for further treatment. CONCLUSIONS:Based on the results of blood calture,clinical symptoms and the characteristics of drug effects,clinical pharmacists participated in the treatment for the patient with severe infection,retrieved related treatment guideline,assisted physicians to adjust anti-infective plan and close-ly monitored possible ADR so as to guarantee the effectiveness and safety of anti-infective treatment.
