Relation of Toll-like Receptor 4 and Monocyte Chemoattractant Protein-1 with Acute Coronary Syndrome
10.3969/j.issn.1671-7414.2016.05.022
- VernacularTitle:Toll样受体4和单核细胞趋化蛋白1与急性冠脉综合征的关系研究
- Author:
Hui WANG
;
Bo WANG
;
Xuan GUO
- Publication Type:Journal Article
- Keywords:
Toll-like receptor 4 (TLR4);
monocyte chemoattractant protein-1 (MCP-1);
acute coronary syndrome;
unstable angina;
acute myocardial infarction
- From:
Journal of Modern Laboratory Medicine
2016;31(5):84-87
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relation of Toll-like receptor 4 (TLR4)and monocyte chemoattractant protein-1 (MCP-1)with acute coronary syndrome.Methods 60 patients with coronary heart disease patients including 39 cases of a-cute coronary syndrome (ACS group),21 cases of stable angina (SA group)from January 2015-March 2016 in Xi’an First Hospital were in this observation.ACS group was divided into acute myocardial infarction (AMI,n=21)and unstable angina pectoris (UAP,n=18).Another 30 cases with angiographically normal was included in control group.Enzyme-linked immu-nosorbent assay (ELISA)detection was used to detect the serum content of MCP-1,TLR4 expression was tested by flow cy-tometry.Triglyceride (TG),total cholesterol (TC),low-density lipoprotein cholesterol (LDL-C)and high-density lipopro-tein cholesterol (HDL-C)were detected.Results TLR4 levels of ACS group was significantly higher than SA group (t=4.455,P=0.021).Serum MCP-1 levels of ACS group were significantly higher than SA group (t=3.220,P=0.002)and control group (t=6.197,P=0.000).MCP-1 levels of ACS group were higher than control group (t=2.306,P=0.025). The Spearman correlation test TLR4 was positively with MCP-1 (r=2.389,P=0.025).Conclusion MCP-1 and TLR4 may determine the severity of coronary heart disease,combined detection of MCP-1 and TRL4 can provide the clinical value for early diagnosis and treatment of ACS.
