Clinical Significance of Neutrophils/Lymphocyte of Peripheral Blood in Patients with Primary Biliary Cirrhosis

VernacularTitle:原发性胆汁性肝硬化患者外周血中性粒细胞／淋巴细胞比值及其临床意义
Author: Tingting LIU ; Mingli GU ; Lei ZHANG ; Xin YE ; Yan CHEN ; Qin QIN ; Anmei DENG
Publication Type:Journal Article
Keywords: primary biliary cirrhosis; neutrophils/lymphocyte ratio
From: Journal of Modern Laboratory Medicine 2016;31(5):127-129
CountryChina
Language:Chinese
Abstract: Objective To explore the clinical significance of neutrophils/lymphocyte(NLR)and platelet/lymphocyte ratioof (PLR)peripheral blood in patients with primary biliary cirrhosis.Methods Retrospectively analyzed 62 patients with PBC and three subgroup patients according to Child-pugh,who were hospitalized in Shanghai Changhai Hospital and Shanghai Changzheng Hospital from January 2010 to July 2015.Enrolled 59 healthy controls.Baseline data and laboratory indicators were extracted,and the correlation between PLR and NLR and disease activity were analyzed.The changes of NLR in 3 pa-tients with PBC were analyzed.3 patients were followed up and their NLRs were recorded before and after therapy.Results Compared with healthy controls,NLR was significantly increased in PBC patients (P<0.05),and not PLR (P>0.05). NLR was positively correlated with TBIL and Mayo risk (R=0.35,0.30,P<0.05),and not ALT,AST or ALP (P>0.05).After therapy,NLRs were significantly reduced in three PBC patients (P<0.05).Conclusion NLR may be a useful biomarker for assessing clinical therapy in PBC patients.