Research on Expression of FAK in Prostate Carcinoma
10.3969/j.issn.1671-7414.2016.05.038
- VernacularTitle:粘着斑激酶在前列腺癌中表达的研究
- Author:
Hongli LIAO
- Publication Type:Journal Article
- Keywords:
prostate carcinoma(PC);
focal adhesion kinase (FAK);
immunohistochemical
- From:
Journal of Modern Laboratory Medicine
2016;31(5):132-133
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationships between expression of FAK and Prostate Carcinoma (PC)morbidity. Methods By surgery,get cancer tissue and para-carcinama tissue from 60 cases PC.To detect FAK expression by immuno-histochemical.To extract total RNA by Trizol.To detect the FAK mRNA by RT-PCR,and analysis these data.Results FAK expression level in cancer tissue was higher than that in para-carcinama tissue.There was statistical difference between them (χ2=72.55,P<0.01).mRNA expression levels of FAK in cancer tissue showed significant higher than the levels in para-carcinama tissue (t=30.51,P<0.01).According to lymphatic metastasis,the expression positive cases of FAK in pN0M0 classification were lower than these in pN3M1 classification,and mRNA expression levels of FAK were the same re-sults.There were clearly statistical distinctive (t=25.43,P<0.01).Conclusion The expression of FAK in PC cells was as-sociated with tumor invasion.
