Role of PERK/eIF2α signaling pathway in systemic damages resulted from fluorosis
10.3760/cma.j.issn.2095-4255.2016.09.019
- VernacularTitle:PERK/p-eIF2a通路在氟致机体损伤中的作用
- Author:
Shize WANG
;
Wei WEI
;
Dianjun SUN
- Publication Type:Journal Article
- Keywords:
Fluorosis;
PERK/eIF2α signaling pathway;
Pathogenesis
- From:
Chinese Journal of Endemiology
2016;35(9):698-702
- CountryChina
- Language:Chinese
-
Abstract:
Fluoride can cause phrenology and non-phrenology damage,but the mechanisms were unclear.It is reported that fluoride can decrease protein synthesis and induce cell apoptosis,leading to extensive systemic damage.Many studies have found that the mechanism is closely associated with endoplasmic reticulum stress.Protein kinase receptor-like ER kinase/Eukaryotic translation initiation factor 2α (PERK/eIF2α) signaling pathway is the first activation pathway when endoplasmic reticulum stress occurs which may play an important role in the pathogenesis of fluorosis.This present paper is focused on the role of PERK/elF2α signaling pathway-related factors in the systemic and organism damages resulted from fluorosis,which may provide new ideas in mechanism and prevention of fluorosis.
